Topological Schr\"odinger cats: Non-local quantum superpositions of topological defects

Topological defects (such as monopoles, vortex lines, or domain walls) mark locations where disparate choices of a broken symmetry vacuum elsewhere in the system lead to irreconcilable differences. They are energetically costly (the energy density in their core reaches that of the prior symmetric vacuum) but topologically stable (the whole manifold would have to be rearranged to get rid of the defect). We show how, in a paradigmatic model of a quantum phase transition, a topological defect can be put in a non-local superposition, so that - in a region large compared to the size of its core - the order parameter of the system is "undecided" by being in a quantum superposition of conflicting choices of the broken symmetry. We demonstrate how to exhibit such a "Schr\"odinger kink" by devising a version of a double-slit experiment suitable for topological defects. Coherence detectable in such experiments will be suppressed as a consequence of interaction with the environment. We analyze environment-induced decoherence and discuss its role in symmetry breaking.Comment: 7 pages, 4 figure

Consistent quantum mechanics admits no mereotopology

It is standardly assumed in discussions of quantum theory that physical systems can be regarded as having well-defined Hilbert spaces. It is shown here that a Hilbert space can be consistently partitioned only if its components are assumed not to interact. The assumption that physical systems have well-defined Hilbert spaces is, therefore, physically unwarranted.Comment: 10 pages; to appear in Axiomathe

Provenance and tectonic setting of the Neoproterozoic Yanbian Group, western Yangtze Block (SW China)

Tectonic evolution of the Yangtze Block of South China during Neoproterozoic time has been a major focus of debate and is important in the reconstruction of the Rodinian supercontinent. The Yanbian Group in the western margin of the Yangtze Block is a well-preserved Neoproterozoic volcanic-sedimentary sequence and provides a rare opportunity to examine the provenance and tectonic setting. It consists of a lower part composed of ∼1500 m thick basaltic lavas and an upper part of ∼3500 m thick flysch deposits. The flysch sequence contains typical deep marine turbidites consisting mainly of fine-grained volcaniclastic sandstones and mudstones, indicating a submarine fan depositional system. Detrital zircon dating yields ages ranging from ca. 865 Ma to 1000 Ma with two peaks at ca. 900 Ma and 920 Ma, respectively. The Yanbian Group is intruded by the ∼860 Ma Guandaoshan dioritic pluton, constraining its depositional age at ca. 870 Ma. The sandstones contain abundant feldspar and lithic fragments with minor amounts of quartz and have an average composition of Q 16F 35L 49, suggesting a proximal source and an undissected to transitional arc setting. The lithic fragments in the sandstones point to andesitic and felsic volcanic rock sources. The sandstones and mudstones have intermediate SiO 2/Al 2O 3 (typically 3-6), high Fe 2O 3 + MgO contents (5-12 wt%), and moderate to high K 2O/Na 2O ratios (generally 0.1-1 and 1-10 for sandstones and mudstones, respectively). In comparison with average upper continental crust, they show strong negative Nb-Ta anomalies, slight depletion of Zr-Hf, La and Th, but moderate enrichment of V, Cr, Ni, and Sc. These rocks show LREE enrichment (La/Yb N = 5.3-7.4) with flat HREE, and pronounced negative Eu anomalies (Eu/Eu * = 0.6-0.74) in chondrite-normalized REE patterns, similar to post-Archean shales. Geochemical data for these rocks suggest an arc setting and intermediate-felsic volcanic source, consistent with a back-arc basin scenario for the basaltic lavas in the lower Yanbian Group. Together with regional geological evidence, the turbidites of the Yanbian Group strongly support a model in which the western margin of the Yangtze Block was a major magmatic arc, active probably from ∼920 Ma to 740 Ma, a period of more than 180 million years. © 2008 Elsevier B.V. All rights reserved.postprin

Towards the design of resilient waste-to-energy systems using Bayesian networks

The concept of resilience has emerged from various domains to address how systems, people and organizations can handle uncertainty. This paper presents a method to improve the resilience of an engineering system by maximizing the system economic lifecycle value, as measured by Net Present Value, under uncertainty. The method is applied to a Waste-to-Energy system based in Singapore and the impact of combining robust and flexible design strategies to improve resilience are discussed. Robust strategies involve optimizing the initial capacity of the system while Bayesian Networks are implemented to choose the flexible expansion strategy that should be deployed given the current observations of demand uncertainties. The Bayesian Network shows promise and should be considered further where decisions are more complex. Resilience is further assessed by varying the volatility of the stochastic demand in the simulation. Increasing volatility generally made the system perform worse since not all demand could be converted to revenue due to capacity constraints. Flexibility shows increased value compared to a fixed design. However, when the system is allowed to upgrade too often, the costs of implementation negates the revenue increase. The better design is to have a high initial capacity, such that there is less restriction on the demand with two or three expansions.</jats:p

Quality of Care for Older Patients with Non-Cancer Diagnoses under the End-of-Life Care Program

Background: End-of-life (EOL) care is an important part of geriatric medicine in view of rapidly ageing populations in the world. Aim: We aimed to evaluate the quality of care for older patients with non-cancer terminal illnesses, who died in 2010, under the EOL care program of an academic medical unit in Hong Kong. This unit consisted of an acute hospital, Prince of Wales Hospital (PWH) and a convalescence hospital (Shatin Hospital, SH). Methods: This was a retrospective hospital-based audit of clinical effectiveness of the EOL service. We reviewed the quality of patient care during the final seven days of life. The quality of care was evaluated based on the compliance rates of five selected goals and the adoption of futile life-sustaining procedures and treatments. Results: Case records of 129 patients in the EOL care program were analyzed. Two goals, including minimization of regular monitoring of vital signs and no blood taking, achieved over 70% compliance at SH and 0% at PWH. The compliance rates of discontinuation of non-essential medications were 46.4% in SH and 47.1% in PWH; and the compliance rates of switching essential medications to non-oral routes were 63.4% in SH and 70.6% in PWH (not statistically significant). The compliance rates of using as-required intravenous or subcutaneous medications were extremely low (<2%) at both hospitals. All futile life-sustaining procedures and treatments were initiated at the PWH. Conclusions: We demonstrated significant differences in the quality of EOL care between the acute hospital and convalescence hospital. Greater emphasis on specialist training and education with allocation of resources may improve the EOL care in both settings.published_or_final_versio

Primary Superficial Vein Reflux with Competent Saphenous Trunk

AbstractObjectives: because reflux in superficial vein tributaries is most often collectively reported with the main saphenous veins, its importance remains largely unrecognised. This study was designed to identify the distribution and extent of non-truncal superficial venous reflux and its association with the signs and symptoms of chronic venous disease (CVD). Patients and methods: eighty-four limbs in 62 patients with signs and symptoms of CVD and evidence of reflux on continuous-wave Doppler were subsequently examined with colour-flow duplex imaging. Incompetent superficial vein tributaries were imaged throughout their extent and both ends were identified. Limbs with reflux in the main trunk of the saphenous veins or the deep, perforator or muscular veins, superficial or deep vein thrombosis, injection sclerotherapy, varicose-vein surgery, arterial disease and inflammation of non-venous origin were excluded from the study. The CEAP classification system was used for staging clinical severity of CVD. Results: the prevalence of tributary reflux alone was 9.7% (84/860). Reflux was detected in 171 tributaries. The number of incompetent tributaries ranged from 1 to 5 per limb. Most prevalent were the tributaries to the greater saphenous (111, 65%<0.0001), followed by those of lesser saphenous (33, 19%) or a combination of both (12, 7%). Incompetent non-saphenous tributaries were uncommon (15, 9%). Among the named tributaries in the lower limb the posterior arch vein was most often incompetent (46, 27%) followed by the anterolateral vein of the thigh (30, 18%), the medial accessory vein (16, 9%) and the anterior arch vein (14, 8%). Reflux in above-the-knee tributaries alone was found in 18 limbs (21%), in below the knee in 23 (28%) and in both sites in 43 (51%). The vast majority of the limbs (71%,p <0.0001) belonged to CVD class 2, 14% in class 3, 9% in class 1 and only 6% in class 4. Class 3 and 4 patients tended to have a longer duration of signs and symptoms, higher number of incompetent tributaries per limb and also a higher prevalence of combined above- and below-knee reflux. Conclusions: these data indicate that reflux confined to superficial tributaries is found throughout the lower limb. Because this reflux is present without greater and lesser saphenous trunk, perforator and deep-vein incompetence or proximal obstruction, it shows that reflux can develop in any vein without an apparent feeding source. Greater saphenous tributaries are affected significantly more often than those of lesser saphenous, while non-saphenous reflux is uncommon. Most limbs have signs and symptoms of CVD class 2 and 15% belong in classes 3 and 4

Angiotensin II receptor blockade alleviates calcineurin inhibitor nephrotoxicity by restoring cyclooxygenase 2 expression in kidney cortex

Aim: The use of calcineurin inhibitors such as cyclosporine A (CsA) for immunosuppression after solid organ transplantation is commonly limited by renal side effects. CsA-induced deterioration of glomerular filtration rate and sodium retention may be related to juxtaglomerular dysregulation as a result of suppressed cyclooxygenase 2 (COX-2) and stimulated renin biosynthesis. We tested whether CsA-induced COX-2 suppression is caused by hyperactive renin-angiotensin system (RAS) and whether RAS inhibition may alleviate the related side effects. Methods: Rats received CsA, the RAS inhibitor candesartan, or the COX-2 inhibitor celecoxib acutely (3 days) or chronically (3 weeks). Molecular pathways mediating effects of CsA and RAS on COX-2 were studied in cultured macula densa cells. Results: Pharmacological or siRNA-mediated calcineurin inhibition in cultured cells enhanced COX-2 expression via p38 mitogen-activated protein kinase and NF-kB signalling, whereas angiotensin II abolished these effects. Acute and chronic CsA administration to rats led to RAS activation along with reduced cortical COX-2 expression, creatinine clearance and fractional sodium excretion. Evaluation of major distal salt transporters, NKCC2 and NCC, showed increased levels of their activating phosphorylation upon CsA. Concomitant candesartan treatment blunted these effects acutely and completely normalized the COX-2 expression and renal functional parameters at long term. Celecoxib prevented the candesartan-induced improvements of creatinine clearance and sodium excretion. Conclusion: Suppression of juxtaglomerular COX-2 upon CsA results from RAS activation, which overrides the cell-autonomous, COX-2-stimulatory effects of calcineurin inhibition. Angiotensin II antagonism alleviates CsA nephrotoxicity via the COX-2-dependent normalization of creatinine clearance and sodium excretion

Realization of GHZ States and the GHZ Test via Cavity QED

In this article we discuss the realization of atomic GHZ states involving three-level atoms and we show explicitly how to use this state to perform the GHZ test in which it is possible to decide between local realism theories and quantum mechanics. The experimental realizations proposed makes use of the interaction of Rydberg atoms with a cavity prepared in a coherent state.Comment: 16 pages and 3 figures. submitted to J. Mod. Op

New mean field theories for the liquid-vapor transition of charged hard spheres

The phase behavior of the primitive model of electrolytes is studied in the framework of various mean field approximations obtained recently by means of methods pertaining to statistical field theory (CAILLOL, J.-M., 2004, \textit{J. Stat. Phys.}, \textbf{115}, 1461). The role of the regularization of the Coulomb potential at short distances is discussed in details and the link with more traditional approximations of the theory of liquids is discussed. The values computed for the critical temperatures, chemical potentials, and densities are compared with available Monte Carlo data and other theoretical predictions.Comment: 17 pages, 4 figures, 3 table